Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

[HTML][HTML] Multinuclear metal catalysts in ring-opening polymerization of ε‑caprolactone and lactide: Cooperative and electronic effects between metal centers

LJ Wu, W Lee, PK Ganta, YL Chang, YC Chang… - Coordination Chemistry …, 2023 - Elsevier
Multinuclear metal complexes can effectively improve the catalytic activity of catalysts for ring-
opening polymerization (ROP) of cyclic esters. If the catalytic metal centers are close enough …

Recent advances in polycaprolactones for anticancer drug delivery

A Bhadran, T Shah, GK Babanyinah, H Polara… - Pharmaceutics, 2023 - mdpi.com
Poly (ε-Caprolactone) s are biodegradable and biocompatible polyesters that have gained
considerable attention for drug delivery applications due to their slow degradation and ease …

Strong, resilient, and sustainable aliphatic polyester thermoplastic elastomers

A Watts, N Kurokawa, MA Hillmyer - Biomacromolecules, 2017 - ACS Publications
Thermoplastic elastomers (TPEs) composed of ABA block polymers exhibit a wide variety of
properties and are easily processable as they contain physical, rather than chemical, cross …

Double hydrophilic block copolymers self-assemblies in biomedical applications

A El Jundi, SJ Buwalda, Y Bakkour, X Garric… - Advances in colloid and …, 2020 - Elsevier
Double-hydrophilic block copolymers (DHBCs), consisting of at least two different water-
soluble blocks, are an alternative to the classical amphiphilic block copolymers and have …

Enzyme-Triggered Degradation of Supramolecularly Cross-Linked Polymersomes of Azobenzene-Based Polyurethane: Cell-Selective Anticancer Drug Release

S Kolay, M Das, A Mondal, A Sengupta, S Bag… - …, 2024 - ACS Publications
Enzyme-responsive self-assembled nanostructures for drug delivery applications have
gained a lot of attention, as enzymes exhibit dysregulation in many disease-associated …

Reversible cross-linked thermoresponsive polycaprolactone micelles for enhanced stability and controlled release

A Bhadran, H Polara, EL Calubaquib, H Wang… - …, 2023 - ACS Publications
Thermoresponsive amphiphilic poly (ε-caprolactone) s (PCL) s are excellent candidates for
drug delivery due to their biodegradability, biocompatibility, and controlled release …

New chemistry in functional aliphatic polyesters

R Tong - Industrial & Engineering Chemistry Research, 2017 - ACS Publications
Aliphatic polyesters are important biodegradable polymers with wide applications.
Polyesters prepared by ring-opening polymerization often have a limited range of properties …

Polymersome Formation by Amphiphilic Polyglycerol-b-polydisulfide-b-polyglycerol and Glutathione-Triggered Intracellular Drug Delivery

R Bej, K Achazi, R Haag, S Ghosh - Biomacromolecules, 2020 - ACS Publications
This article reports the synthesis, spontaneous self-assembly, highly efficient drug
encapsulation, and glutathione (GSH)-triggered intracellular sustained drug delivery of an …

Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery

GK Babanyinah, A Bhadran, H Polara, H Wang… - Chemical …, 2024 - pubs.rsc.org
High glutathione production is known to be one of the defense mechanisms by which many
cancer cells survive elevated oxidative stress. By explicitly targeting glutathione in these …