Abstract Gamma-linolenic acid (GLA, 18: 3n-6) is an omega-6 (n-6), 18 carbon (18C-)
polyunsaturated fatty acid (PUFA) found in human milk and several botanical seed oils and …

Desaturase and elongase-limiting endogenous long-chain polyu... : Current Opinion in Clinical
Nutrition & Metabolic Care Desaturase and elongase-limiting endogenous long-chain …

Background: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-)
polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be …

FADS genes encode fatty acid desaturases that are important for the conversion of short
chain polyunsaturated fatty acids (PUFAs) to long chain fatty acids. Prior studies indicate that …

Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a
genome-wide association study of 19,219 individuals, we found 38 new variants and …

Humans have undergone intense evolutionary selection to optimize their capacity to
generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA) …

Simple Summary On a system level, multi-omics approaches allow studying oxylipins,
metabolites of omega-3 or omega-6 polyunsaturated fatty acids. We compared the ultra-high …

Long chain polyunsaturated fatty acids (LCPUFA) are bioactive components of membrane
phospholipids and serve as substrates for signaling molecules. LCPUFA can be obtained …

Human diets in developed countries such as the US have changed dramatically over the
past 75 years, leading to increased obesity, inflammation, and cardiometabolic dysfunction …

The aim of this review was to determine the impact of the fatty acid desaturase (FADS)
genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including …