The initiation of eukaryotic DNA replication
A Costa, JFX Diffley - Annual review of biochemistry, 2022 - annualreviews.org
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
Acetylation of histones and transcription-related factors
DE Sterner, SL Berger - Microbiology and molecular biology …, 2000 - Am Soc Microbiol
The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …
have major effects on levels of gene expression, and numerous chromatin-altering …
Eukaryotic DNA replication origins: many choices for appropriate answers
M Méchali - Nature reviews Molecular cell biology, 2010 - nature.com
At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …
remains unclear how they are selected and recognized by replication factors. DNA …
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
CB Brachmann, JM Sherman, SE Devine… - Genes & …, 1995 - genesdev.cshlp.org
Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is
known about conserved mechanisms of silencing. We report here the discovery of four …
known about conserved mechanisms of silencing. We report here the discovery of four …
The Establishment, Inheritance, and Function of Silenced Chromatin in Saccharomyces cerevisiae
▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …
regions known as heterochromatin, or silenced chromatin. This review describes …
Mechanisms and regulation of DNA replication initiation in eukaryotes
MW Parker, MR Botchan, JM Berger - Critical reviews in …, 2017 - Taylor & Francis
Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
P Moretti, K Freeman, L Coodly… - Genes & …, 1994 - genesdev.cshlp.org
The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast
requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding …
requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding …
Chromosome dynamics in the yeast interphase nucleus
Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four
chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored …
chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored …
Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
RC Allshire, ER Nimmo, K Ekwall… - Genes & …, 1995 - genesdev.cshlp.org
The ura4+ gene displays phenotypes consistent with variegated expression when inserted
at 11 sites throughout fission yeast centromere 1. An abrupt transition occurs between the …
at 11 sites throughout fission yeast centromere 1. An abrupt transition occurs between the …
A DNA helicase activity is associated with an MCM4,-6, and-7 protein complex
Y Ishimi - Journal of Biological Chemistry, 1997 - ASBMB
All six minichromosome maintenance (MCM) proteins have DNA-dependent ATPase motifs
in the central domain which is conserved from yeast to mammals. Our group purified MCM …
in the central domain which is conserved from yeast to mammals. Our group purified MCM …