Comprehensive summary: the role of PBX1 in development and cancers

M Liu, Y Xing, J Tan, X Chen, Y Xue, L Qu… - Frontiers in Cell and …, 2024 - frontiersin.org
PBX1 is a transcription factor that can promote the occurrence of various tumors and play a
reg-ulatory role in tumor growth, metastasis, invasion, and drug resistance. Furthermore, a …

Homeobox and Polycomb target gene methylation in human solid tumors

R Blanchett, KH Lau, GP Pfeifer - Scientific Reports, 2024 - nature.com
DNA methylation is an epigenetic mark that plays an important role in defining cancer
phenotypes, with global hypomethylation and focal hypermethylation at CpG islands …

Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer

W Dai, Y Liu, T Zhang, Z Huang, X Xu, Z Zhao, J Liu… - Oncogenesis, 2023 - nature.com
PBX1 is a transcription factor that regulates a variety of genes, involved in intracellular lipid
metabolism, cell proliferation, and other pathways. The promoting and inhibiting function of …

N6-methyladenosine modification and post-translational modification of epithelial–mesenchymal transition in colorectal cancer

Y Wang, Y Chen, M Zhao - Discover Oncology, 2024 - Springer
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally,
colorectal cancer has been recognized as a disease caused by genetic mutations. However …

Identifying the potential roles of PBX4 in human cancers based on integrative analysis

Y Song, R Ma - Biomolecules, 2022 - mdpi.com
PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and
acts as a transcriptional cofactor of HOX proteins participating in several pathophysiological …

New insight into mechanisms of hepatic encephalopathy: an integrative analysis approach to identify molecular markers and therapeutic targets

A Sepehrinezhad, A Shahbazi… - … and biology insights, 2023 - journals.sagepub.com
Hepatic encephalopathy (HE) is a set of complex neurological complications that arise from
advanced liver disease. The precise molecular and cellular mechanism of HE is not fully …

Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal …

TM Nguyen, X Geng, Y Wei, L Ye, DJ Garry… - … in Bioengineering and …, 2024 - frontiersin.org
Background: In our previous work, we demonstrated that when newborn pigs undergo apical
resection (AR) on postnatal day 1 (P1), the animals' hearts were completely recover from a …

Development of a novel transcription factor signature for accurate cervical cancer prognosis.

S Chen, X Li, T He, X Chen, X Tang… - European Journal …, 2023 - search.ebscohost.com
Cervical cancer (CC) is a leading cause of cancer-related deaths in women. During tumor
development, transcriptional factors regulate the transcription of proto-oncogenes and tumor …

Correlation analysis of PBX family with immune invasion and drug sensitivity in colon adenocarcinoma

G Chao, L Zhang - Heliyon, 2023 - cell.com
Objedtive Pre-B cell leukemia (PBX) has been found to be associated with cancer, but
poorly studied with colon adenocarcinoma (COAD). In this study, the correlation between …

Identification of the driving mechanisms associated with aggressive transformation and prognosis in follicular lymphomas

X Li, R Wang, X Chen, Y Yu, C He, Q Zhang - 2022 - researchsquare.com
Follicular lymphoma (FL) is the most frequently common indolent subtype of non-Hodgkin's
lymphoma (NHL), with a generally favorable prognosis. Recent studies have elucidated a …