Pediatric central nervous system (CNS) tumors are the second most common childhood
malignancy and the most common solid tumor in children. The incidence rate of childhood …

Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants.
Although the prognosis of ATRT patients is poor, some patients respond favorably to current …

Epigenetic alterations have been increasingly implicated in oncogenesis. Analysis of
Drosophila mutants suggests that Polycomb and SWI/SNF complexes can serve …

PURPOSE Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain
tumor without standard effective treatment. To our knowledge, we conducted the first AT/RT …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms …

Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of
children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in …

Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the
past 5 years. This article summarizes data from collaborative group and institutional trials …

Rhabdoid tumors of early infancy are highly aggressive with consequent poor prognosis.
Most cases show inactivation of the SMARCB1 (also known as INI1 and hSNF5) tumor …

Background Controversy exists as to what may be defined as standard of care (including
markers for stratification) for patients with atypical teratoid/rhabdoid tumors (ATRTs). The …