Advancing human disease research with fish evolutionary mutant models
Model organism research is essential to understand disease mechanisms. However,
laboratory-induced genetic models can lack genetic variation and often fail to mimic the …
laboratory-induced genetic models can lack genetic variation and often fail to mimic the …
Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes
Background Genetic studies have associated thousands of enhancers with breast cancer
(BC). However, the vast majority have not been functionally characterized. Thus, it remains …
(BC). However, the vast majority have not been functionally characterized. Thus, it remains …
Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications
AA Abbasi - Development genes and evolution, 2015 - Springer
HOX genes encode transcriptional factors that play a pivotal role in specifying regional
identity in nearly every bilateral animal. The birth of HOX gene cluster and its subsequent …
identity in nearly every bilateral animal. The birth of HOX gene cluster and its subsequent …
Identification of ancestral gnathostome Gli3 enhancers with activity in mammals
Abnormal expression of the transcriptional regulator and hedgehog (Hh) signaling pathway
effector Gli3 is known to trigger congenital disease, most frequently affecting the central …
effector Gli3 is known to trigger congenital disease, most frequently affecting the central …
The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
Background Robustness and evolutionary stability of gene expression in the human
genome are established by an array of redundant enhancers. Results Using Hi-C data in …
genome are established by an array of redundant enhancers. Results Using Hi-C data in …
Cis‐regulatory control of mammalian Trps1 gene expression
TRPS1 serves as the causative gene for tricho‐rhino phalangeal syndrome, known for its
craniofacial and skeletal abnormalities. The Trps1 gene encodes a protein that represses …
craniofacial and skeletal abnormalities. The Trps1 gene encodes a protein that represses …
Predicting genome‐wide tissue‐specific enhancers via combinatorial transcription factor genomic occupancy analysis
Enhancers are non‐coding cis‐regulatory elements crucial for transcriptional regulation.
Mutations in enhancers can disrupt gene regulation, leading to disease phenotypes …
Mutations in enhancers can disrupt gene regulation, leading to disease phenotypes …
Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions
H Khatoon, RZ Raza, S Saleem, F Batool… - BMC Molecular and Cell …, 2023 - Springer
Abstract Background Human accelerated regions (HARs) are short conserved genomic
sequences that have acquired significantly more nucleotide substitutions than expected in …
sequences that have acquired significantly more nucleotide substitutions than expected in …
Whole genome comparative analysis of channel catfish (Ictalurus punctatus) with four model fish species
Background Comparative mapping is a powerful tool to study evolution of genomes. It allows
transfer of genome information from the well-studied model species to non-model species …
transfer of genome information from the well-studied model species to non-model species …
The evolution of bony vertebrate enhancers at odds with their coding sequence landscape
A Yousaf, M Sohail Raza… - Genome biology and …, 2015 - academic.oup.com
Enhancers lie at the heart of transcriptional and developmental gene regulation. Therefore,
changes in enhancer sequences usually disrupt the target gene expression and result in …
changes in enhancer sequences usually disrupt the target gene expression and result in …