The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …
Materials as stem cell regulators
The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …
and the material cooperatively dictate one another's fate: the cell by remodelling its …
The myofibroblast at a glance
In 1971, Gabbiani and co-workers discovered and characterized the “modification of
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …
Platelet-rich plasma: a milieu of bioactive factors
SG Boswell, BJ Cole, EA Sundman, V Karas… - Arthroscopy: The journal …, 2012 - Elsevier
Platelet concentrates such as platelet-rich plasma (PRP) have gained popularity in sports
medicine and orthopaedics to promote accelerated physiologic healing and return to …
medicine and orthopaedics to promote accelerated physiologic healing and return to …
Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue
GS Karagiannis, T Poutahidis, SE Erdman… - Molecular cancer …, 2012 - AACR
Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …
The myofibroblast, a key cell in normal and pathological tissue repair
Myofibroblasts are characterized by their expression of α-smooth muscle actin, their
enhanced contractility when compared to normal fibroblasts and their increased synthetic …
enhanced contractility when compared to normal fibroblasts and their increased synthetic …
Liver stiffness: a novel parameter for the diagnosis of liver disease
S Mueller, L Sandrin - Hepatic medicine: evidence and research, 2010 - Taylor & Francis
The noninvasive quantitation of liver stiffness (LS) by ultrasound based transient
elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely …
elastography using FibroScan® has revolutionized the diagnosis of liver diseases, namely …
From mechanical loading to collagen synthesis, structural changes and function in human tendon
M Kjær, H Langberg, K Heinemeier… - … journal of medicine …, 2009 - Wiley Online Library
The adaptive response of connective tissue to loading requires increased synthesis and
turnover of matrix proteins, with special emphasis on collagen. Collagen formation and …
turnover of matrix proteins, with special emphasis on collagen. Collagen formation and …
Direct effects of empagliflozin on extracellular matrix remodelling in human cardiac myofibroblasts: novel translational clues to explain EMPA-REG OUTCOME results
S Kang, S Verma, AF Hassanabad, G Teng… - Canadian Journal of …, 2020 - Elsevier
Background Empagliflozin, an SGLT2 inhibitor, has shown remarkable reductions in
cardiovascular mortality and heart failure admissions (EMPA-REG OUTCOME). However …
cardiovascular mortality and heart failure admissions (EMPA-REG OUTCOME). However …