Respect for the primary cilium has undergone a remarkable renaissance over the past
decade, and it is now thought to be an essential regulator of numerous signaling pathways …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Summary Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes
are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration …

The assembly of primary cilia is dependant on intraflagellar transport (IFT), which mediates
the bidirectional movement of proteins between the base and tip of the cilium. In mice …

Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, represents the
most frequent genetic cause of end-stage kidney disease in the first three decades of life …

Cilia are complex organelles involved in sensory perception and fluid or cell movement.
They are constructed through a highly conserved process called intraflagellar transport (IFT) …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney
disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 …

Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the
accumulation of cysts in the renal parenchyma and progressive decline in renal function …

Solitary primary cilia project from nearly every cell type in the human body. These organelles
are considered to have important sensory and signaling functions. Although primary cilia …