Strategies to address mesenchymal stem/stromal cell heterogeneity in immunomodulatory profiles to improve cell-based therapies

CM Dunn, S Kameishi, DW Grainger, T Okano - Acta Biomaterialia, 2021 - Elsevier
Mesenchymal stromal cells (MSCs) have gained immense attention over the past two
decades due to their multipotent differentiation potential and pro-regenerative and …

Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease Using Commercial Mesenchymal Stem Cell Products

M Murata, T Teshima - Frontiers in Immunology, 2021 - frontiersin.org
Acute graft-versus-host disease (GVHD) is a life-threatening complication that can develop
after allogeneic hematopoietic stem cell transplantation. In particular, the prognosis of …

[HTML][HTML] Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

NM Drzeniek, A Mazzocchi, S Schlickeiser… - …, 2021 - iopscience.iop.org
The therapeutic efficacy of clinically applied mesenchymal stromal cells (MSCs) is limited
due to their injection into harsh in vivo environments, resulting in the significant loss of their …

Global microRNA profiling of bone marrow-MSC derived extracellular vesicles identifies miRNAs associated with hematopoietic dysfunction in aplastic anemia

J Srivastava, K Kundal, B Rai, P Saxena, S Katiyar… - Scientific Reports, 2024 - nature.com
Recently, we have reported that extracellular vesicles (EVs) from the bone marrow
mesenchymal stromal cells (BM-MSC) of aplastic anemia (AA) patients inhibit hematopoietic …

The cellular composition and function of the bone marrow niche after allogeneic hematopoietic cell transplantation

F Peci, L Dekker, A Pagliaro, R van Boxtel… - Bone marrow …, 2022 - nature.com
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for
patients with a variety of malignant and non-malignant diseases. Despite its life-saving …

The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway

T He, B Zhou, G Sun, Q Yan, S Lin, G Ma… - Cell Death & …, 2024 - nature.com
Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and
disorders; however, its mechanism (s) remain incompletely defined. Here we find that bone …

Comparison of CD146+/− mesenchymal stem cells in improving premature ovarian failure

L Zhang, Y Sun, XX Zhang, YB Liu, HY Sun… - Stem Cell Research & …, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are a heterogeneous group of
subpopulations with differentially expressed surface markers. CD146+ MSCs correlate with …

Mechanotransduction in mesenchymal stem cells (MSCs) differentiation: a review

N Raman, SAM Imran… - International Journal of …, 2022 - mdpi.com
Mechanotransduction is the process by which physical force is converted into a biochemical
signal that is used in development and physiology; meanwhile, it is intended for the ability of …

Haploidentical transplants with a G-CSF/ATG-based protocol: Experience from China

ZL Xu, XJ Huang - Blood Reviews, 2023 - Elsevier
Haploidentical donor stem cell transplantation (haplo-SCT) has made great advances in
recent decades. The granulocyte colony-stimulating factor (G-CSF)-and antithymocyte …

Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis

AK Singh, P Prasad, JA Cancelas - Frontiers in Cell and …, 2023 - frontiersin.org
Hematopoietic stem cell (HSC) transplantation-based treatments are in different phases of
clinical development, ranging from current therapies to a promise in the repair and …