Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to
heightened autoimmune response at the articular sites. Worldwide annual incidence and …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Genome-wide association studies (GWASs) are a valuable tool for understanding the
biology of complex human traits and diseases, but associated variants rarely point directly to …

Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has
been implicated in inflammatory conditions, but large-scale metagenomic evaluations have …

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …

RA is a chronic systemic inflammatory disease that primarily affects the small joints of the
hands and feet, and results in a mean reduction in life expectancy of 3–10 years. RA is a …

Three important factors, including genetics, environment factors and autoimmunity play a
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …

High-dimensional single-cell analyses have improved the ability to resolve complex
mixtures of cells from human disease samples; however, identifying disease-associated cell …

Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster
of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently …