Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …

Summary Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-
induced insulin secretion by> 50% with first-and second-phase secretion being equally …

As one of the leading causes of morbidity and mortality worldwide, diabetes affects an
estimated 422 million adults, and it is expected to continue expanding such that by 2050 …

Mathematical modeling in the field of glucose metabolism has a longstanding tradition. The
use of models is motivated by several reasons. Models have been used for calculating …

Initial work on the exocytotic machinery of predocked insulin secretory granules (SGs) in
pancreatic β‐cells mimicked the SNARE hypothesis work in neurons, which includes …

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized
insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging …

The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …