Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

Hypoxia, a widespread occurrence observed in various malignant tumors, results from rapid
tumor growth that outpaces the oxygen supply. Tumor hypoxia precipitates several effects on …

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of
concern (VOCs) that significantly affect global health. This study aims to investigate how …

The adsorption of nonspecific biomolecules on sensing surfaces presents a challenge for
accurate and sensitive detection of targets in complex biological samples, which significantly …

Background Infertility is a global reproductive health burden. Assisted reproductive
technologies (ARTs) have been widely used to help patients become pregnant. Few …

There are only a few options for patients with relapsed/refractory B-cell acute lymphoblastic
leukemia (B-ALL), thus, this is a major area of unmet medical need. In this study, we reveal …

Acylaminoindazole-based inhibitors of CDKL2 were identified via analyses of cell-free
binding and selectivity data. Compound 9 was selected as a CDKL2 chemical probe based …

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of
concern (VOCs) that significantly affect global health. This study aims to investigate how …

Abstract Glycogen Synthase Kinase 3 (GSK-3) functions as a consistently active
serine/threonine kinase that is positioned at the intersection of numerous signaling …

Protein kinase A (PKA), a pivotal serine/threonine kinase in cellular signaling, exerts
profound influence over various vital processes, including gene regulation, cell cycle …