A deep learning-based toolbox for automated limb motion analysis (ALMA) in murine models of neurological disorders

A Aljovic, S Zhao, M Chahin, C de la Rosa… - Communications …, 2022 - nature.com
In neuroscience research, the refined analysis of rodent locomotion is complex and
cumbersome, and access to the technique is limited because of the necessity for expensive …

Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with spinal cord hemisection

E Massai, M Bonizzato, I De Jesus, R Drainville… - eLife, 2024 - elifesciences.org
Control of voluntary limb movement is predominantly attributed to the contralateral motor
cortex. However, increasing evidence suggests the involvement of ipsilateral cortical …

[HTML][HTML] Uncovering and leveraging the return of voluntary motor programs after paralysis using a bi-cortical neuroprosthesis

M Duguay, M Bonizzato, H Delivet-Mongrain… - Progress in …, 2023 - Elsevier
Rehabilitative and neuroprosthetic approaches after spinal cord injury (SCI) aim to
reestablish voluntary control of movement. Promoting recovery requires a mechanistic …

Exercise therapy guides cortical reorganization after midthoracic spinal contusion to enhance control of lower thoracic muscles, supporting functional recovery

B Nandakumar, GH Blumenthal, GD Disse… - Experimental …, 2023 - Elsevier
Postural control is critical for locomotion, allowing for gait changes, obstacle avoidance and
navigation of rough terrain. A major problem after spinal cord injury (SCI) is regaining the …

Targeting the motor cortex to restore walking after incomplete spinal cord injury

M Martinez - Neural Regeneration Research, 2022 - journals.lww.com
Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. The ability
to walk is often lost after SCI, reducing independence and quality of life. Restoration of …

Characterization of Sleep, Emotional, and Cognitive Functions in a New Rat Model of Concomitant Spinal Cord and Traumatic Brain Injuries

M Regniez, J Dufort-Gervais, C Provost… - Journal of …, 2024 - liebertpub.com
Traumatic injuries to the spinal cord or the brain have serious medical consequences and
lead to long-term disability. The epidemiology, medical complications, and prognosis of …

Therapeutic effects of exendin‐4 on spinal cord injury via restoring autophagy function and decreasing necroptosis in neuron

X Gao, QP Li, JR Hao, K Sun, H Feng… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Necroptosis is one of programmed death that may aggravate spinal cord injury (SCI).
We aimed to investigate the effect and mechanism of exendin‐4 (EX‐4) on the recovery of …

[HTML][HTML] Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with incomplete spinal cord injury

E Massai, M Bonizzato, I de Jesus, R Drainville… - eLife, 2023 - elifesciences.org
Control of voluntary limb movement is predominantly attributed to the contralateral motor
cortex. However, increasing evidence suggests the involvement of ipsilateral cortical …

Neural ensemble dynamics in trunk and hindlimb sensorimotor cortex encode for the control of postural stability

GD Disse, B Nandakumar, FP Pauzin, GH Blumenthal… - Cell Reports, 2023 - cell.com
The cortex has a disputed role in monitoring postural equilibrium and intervening in cases of
major postural disturbances. Here, we investigate the patterns of neural activity in the cortex …

Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord

PV Zelenin, VF Lyalka… - The Journal of physiology, 2023 - Wiley Online Library
Acute lateral hemisection of the spinal cord (LHS) severely impairs postural functions, which
recover over time. Here, to reveal changes in the operation of postural networks underlying …