Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Hypoxia is the failure of oxygenation at the tissue level, where the reduced oxygen delivered
is not enough to satisfy tissue demands. Metabolic depression is the physiological …

Prenatal hypoxia often results in dramatic alterations in developmental profiles and
behavioral characteristics, including learning and memory, in later life. Despite the …

Perinatal asphyxia constitutes a prototype of obstetric complications occurring when
pulmonary oxygenation is delayed or interrupted. The primary insult relates to the duration of …

Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to
perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In …

Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates.
Preterm infants have additional complications, as prematurity by itself increases the risk of …

Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to
dopamine, yielding 2 distinct products, ie, salsolinol and isosalsolinol. Early animal studies …

Perinatal asphyxia during delivery produces long-term disability and represents a major
problem in neonatal and pediatric care. Numerous neuroprotective approaches have been …

It is now well established that many of society's most devastating and costly neurological
diseases and disorders arise from trauma at, or shortly after birth. In some cases deficits are …

Perinatal asphyxia (PA) is a leading cause of neuronal damage in newborns, resulting in
long-term neurological and cognitive deficits, in part due to impairment of mesostriatal and …