The adoptive transfer of tumor‐infiltrating lymphocytes (TH.) along with interleukin (H.)‐2 into
autologous patients with cancer resulted in the objective regression of tumor, indicating that …

Transformed cells are characterized by imbalances in metabolic routes. In particular,
different key enzymes of nucleotide metabolism and DNA biosynthesis, such as CTP …

Advanced malignancy in tumours represents the phenotypic end-point of successive genetic
lesions that affect the function and regulation of oncogenes and tumour-suppressor genes …

The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor
activity. Although mice null for the ink4a homolog develop a cancer-prone condition, a …

Tumor infiltrating lymphocytes (TILs) derived from tumor-bearing patients recognize tumor-
associated antigens presented by major histocompatibility complex (MHC) class I …

Genetic studies have implicated the early involvement of a gene on chromosome arm 9p in
the development of cutaneous melanoma. We have performed loss-of-heterozygosity …

Dipeptidyl peptidase IV (DPPIV) is a cell surface peptidase expressed by normal
melanocytes, epithelial cells, and other cells. Malignant cells, including melanomas and …

The availability of antitumor cytotoxic T lymphocytes which can be generated from either
peripheral blood lymphocytes after stimulation in vitro or tumor infiltrating lymphocytes (TIL) …

A series of 2-substituted-4-([1, 2, 4] triazolo [1, 5-a] pyridin-6-yl)-5-(6-methylpyridin-2-yl)
imidazoles was synthesized and evaluated to optimize a prototype inhibitor of TGF-β type I …

The immune system can recognize self antigens expressed by cancer cells. Differentiation
antigens are prototypes of these self antigens, being expressed by cancer cells and their …