2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

MP Wattjes, O Ciccarelli, DS Reich, B Banwell… - The Lancet …, 2021 - thelancet.com
Summary The 2015 Magnetic Resonance Imaging in Multiple Sclerosis and 2016
Consortium of Multiple Sclerosis Centres guidelines on the use of MRI in diagnosis and …

B cells in central nervous system disease: diversity, locations and pathophysiology

RW Jain, VW Yong - Nature Reviews Immunology, 2022 - nature.com
B cells represent a relatively minor cell population within both the healthy and diseased
central nervous system (CNS), yet they can have profound effects. This is emphasized in …

Association of chronic active multiple sclerosis lesions with disability in vivo

M Absinta, P Sati, F Masuzzo, G Nair, V Sethi… - JAMA …, 2019 - jamanetwork.com
Importance In multiple sclerosis (MS), chronic active lesions, which previously could only be
detected at autopsy, can now be identified on susceptibility-based magnetic resonance …

Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines

M Filippi, P Preziosa, BL Banwell, F Barkhof… - Brain, 2019 - academic.oup.com
MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

Role of B cells in multiple sclerosis and related disorders

G Comi, A Bar‐Or, H Lassmann, A Uccelli… - Annals of …, 2021 - Wiley Online Library
The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

How neuroinflammation contributes to neurodegeneration

RM Ransohoff - Science, 2016 - science.org
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

M Absinta, SK Ha, G Nair, P Sati, NJ Luciano… - elife, 2017 - elifesciences.org
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman
primates (common marmoset monkeys) and the feasibility of noninvasively imaging and …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …

Nervous system involvement in coronavirus disease 2019: results from a retrospective consecutive neuroimaging cohort

S Klironomos, A Tzortzakakis, A Kits, C Öhberg… - Radiology, 2020 - pubs.rsna.org
Background Neurologic complications in coronavirus disease 2019 (COVID-19) have been
described, but the understanding of their pathophysiologic causes and neuroanatomical …