The role of ANRIL in atherosclerosis

I Razeghian-Jahromi, A Karimi Akhormeh… - Disease …, 2022 - Wiley Online Library
There is a huge number of noncoding RNA (ncRNA) transcripts in the cell with important
roles in modulation of different mechanisms. ANRIL is a long ncRNA with 3.8 kb length that …

False utopia of one unifying description of the vulnerable atherosclerotic plaque: a call for recalibration that appreciates the diversity of mechanisms leading to …

G Pasterkamp, HM den Ruijter… - … , and vascular biology, 2022 - Am Heart Assoc
Atherosclerosis is a complex disease characterized by the formation of arterial plaques with
a broad diversity of morphological phenotypic presentations. Researchers often apply one …

Polygenic risk score associates with atherosclerotic plaque characteristics at autopsy

A Cornelissen, NV Gadhoke, K Ryan… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Polygenic risk scores (PRSs) for coronary artery disease (CAD) potentially
improve cardiovascular risk prediction. However, their relationship with histopathologic …

Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease

I Razeghian-Jahromi, MJ Zibaeenezhad… - Scientific Reports, 2022 - nature.com
Atherosclerotic lesions of the coronary arteries are still in charge of significant annual
morbidity and mortality despite intense therapeutic advancements. Genome-born elements …

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease

GA Figtree, ST Vernon… - European Journal of …, 2022 - academic.oup.com
Coronary artery disease (CAD) remains the leading cause of death worldwide. The role of
hypertension, cholesterol, diabetes mellitus, and smoking in driving disease has been well …

Combining polygenic and proteomic risk scores with clinical risk factors to improve performance for diagnosing absence of coronary artery disease in patients with de …

PL Møller, PD Rohde, JN Dahl… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Patients with de novo chest pain, referred for evaluation of possible coronary
artery disease (CAD), frequently have an absence of CAD resulting in millions of tests not …

Polygenic risk score–enhanced risk stratification of coronary artery disease in patients with stable chest pain

MK Christiansen, S Winther, L Nissen… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Polygenic risk scores (PRSs) are associated with coronary artery disease
(CAD), but the clinical potential of using PRSs at the single-patient level for risk stratification …

Clinical applications of polygenic risk score for coronary artery disease through the life course

AC Fahed, P Natarajan - Atherosclerosis, 2023 - Elsevier
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality
worldwide, highlighting the limitations of current primary and secondary prevention …

Assessment of cardiovascular disease risk: a 2023 update

E Goldsborough III, E Tasdighi… - Current opinion in …, 2023 - journals.lww.com
Lp (a) concentration and CAC scoring, apart from the traditional risk factors, add the most
value to the current CVD risk assessment approaches of all available tools, especially in …

Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy

S Winther, LD Rasmussen, J Westra… - Open …, 2023 - openheart.bmj.com
Introduction Current guideline recommend functional imaging for myocardial ischaemia if
coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain …