A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the
accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The mechanisms …

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1
protects neurodegeneration by removing damaged mitochondria in Parkinson's disease …

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated
neurodegenerative disorders characterized by the misfolding and aggregation of alpha …

Animal models are extremely valuable to help us understand the pathogenesis of
neurodegenerative disorders and to find treatments for them. Since large animals are more …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Whether direct manipulation of Parkinson's disease (PD) risk genes in the adult monkey
brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an …

Despite the discovery of numerous molecules and pathologies, the pathophysiology of
various neurodegenerative diseases remains unknown. Genetics participates in the …

Neurodegenerative diseases represent a large group of neurological disorders including
Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's …