Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed
predominantly in the skin, mucosa and immune sentinel cells, are key executioners of …

Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer
treatment, and it has achieved unprecedented success in hematological malignancies …