[HTML][HTML] H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine
Cystathionine beta-synthase (CBS) is a pivotal enzyme of the transsulfuration pathway
responsible for diverting homocysteine to the biosynthesis of cysteine and production of …
responsible for diverting homocysteine to the biosynthesis of cysteine and production of …
[HTML][HTML] Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action
Epigallocatechin gallate (EGCG) is the main bioactive component of green tea. Through
screening of a small library of natural compounds, we discovered that EGCG inhibits …
screening of a small library of natural compounds, we discovered that EGCG inhibits …
[HTML][HTML] Insights into Domain Organization and Regulatory Mechanism of Cystathionine Beta-Synthase from Toxoplasma gondii
C Conter, S Fruncillo, F Favretto… - International Journal of …, 2022 - mdpi.com
Cystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although
eukaryotic CBS have a similar domain architecture with a catalytic core and a C-terminal …
eukaryotic CBS have a similar domain architecture with a catalytic core and a C-terminal …
Structural basis of the inhibition of cystathionine γ‐lyase from Toxoplasma gondii by propargylglycine and cysteine
C Fernández‐Rodríguez, C Conter, I Oyenarte… - Protein …, 2023 - Wiley Online Library
Cystathionine γ‐lyase (CGL) is a PLP‐dependent enzyme that catalyzes the last step of the
reverse transsulfuration route for endogenous cysteine biosynthesis. The canonical CGL …
reverse transsulfuration route for endogenous cysteine biosynthesis. The canonical CGL …
Design, synthesis, and bioactivity evaluation of clindamycin derivatives against multidrug‐resistant bacterial strains
Y Jia, Y Zhang, H Zhu, M Wang - Drug Development Research, 2024 - Wiley Online Library
Our research aims to reduce the bacterial resistance of clindamycin against Gram‐positive
bacteria and expand its range of bacterial susceptibility. First, we optimized the structure of …
bacteria and expand its range of bacterial susceptibility. First, we optimized the structure of …
Key substrate recognition residues in the active site of cystathionine beta‐synthase from Toxoplasma gondii
C Conter, F Favretto, P Dominici… - Proteins: Structure …, 2023 - Wiley Online Library
Cystathionine β‐synthase (CBS) catalyzes the condensation of l‐serine and l‐homocysteine
to give l‐cystathionine in the transsulfuration pathway. Recently, a few O‐acetylserine (l …
to give l‐cystathionine in the transsulfuration pathway. Recently, a few O‐acetylserine (l …
Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a
deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 5′-phosphate …
deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 5′-phosphate …