Microcarriers for upscaling cultured meat production

V Bodiou, P Moutsatsou, MJ Post - Frontiers in nutrition, 2020 - frontiersin.org
Due to the considerable environmental impact and the controversial animal welfare
associated with industrial meat production, combined with the ever-increasing global …

The evolution of polystyrene as a cell culture material

MJ Lerman, J Lembong, S Muramoto… - … Engineering Part B …, 2018 - liebertpub.com
Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern
era, propelling dozens of research fields along the way. This review discusses the …

Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges

V Jossen, C van den Bos, R Eibl, D Eibl - Applied microbiology and …, 2018 - Springer
Human mesenchymal stem cell (hMSC)-based therapies are of increasing interest in the
field of regenerative medicine. As economic considerations have shown, allogeneic therapy …

Cellular agriculture: opportunities and challenges

R Eibl, Y Senn, G Gubser, V Jossen… - Annual Review of …, 2021 - annualreviews.org
Cellular agriculture is the controlled and sustainable manufacture of agricultural products
with cells and tissues without plant or animal involvement. Today, microorganisms cultivated …

Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency

KP Robb, JC Fitzgerald, F Barry, S Viswanathan - Cytotherapy, 2019 - Elsevier
Mesenchymal stromal cell (MSC) therapies have been pursued for a broad spectrum of
indications but mixed reports on clinical efficacy have given rise to some degree of …

Mesenchymal stromal cells: from discovery to manufacturing and commercialization

A Mizukami, K Swiech - Stem cells international, 2018 - Wiley Online Library
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense
research by academia and industry due to their unique features. MSC can be easily isolated …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds

PS Couto, MC Rotondi, A Bersenev, CJ Hewitt… - Biotechnology …, 2020 - Elsevier
Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular
intervention for use in cell and gene therapy (CGT) applications due to their …