Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to
specific receptors and transporters that are expressed in many types of cells throughout an …

Pain, although unpleasant, is an essential warning mechanism against injury and damage
of the organism. An intricate network of specialised sensors and transmission systems …

The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel
agents or combination-based analgesic therapies are needed. Herein, oral tolperisone …

Regulation of the ability of a neurotransmitter [our focus: serotonin, norepinephrine,
dopamine, acetylcholine, glycine, and gamma-aminobutyric acid (GABA)] to reach its …

Neuropathic pain is a chronic pain caused by central and peripheral nerve injury, long-term
diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain …

Chronic intermittent hypoxia (CIH), an animal model of sleep apnea, has been shown to
alter the activity of second-order chemoreceptor neurons in the caudal nucleus of the solitary …

Chemotherapy-induced neuropathic pain is a major clinical problem with limited treatment
options. Here, we show that metformin relieves bortezomib (BTZ)-evoked induction and …

There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia
and analgesic tolerance. Opioid analgesics are the mainstay in the management of …

Glycine transporters are interesting therapeutic targets as they play significant roles in
glycinergic and glutamatergic systems. The search for new selective inhibitors of particular …

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts
to develop effective treatments. Animal studies showed that glycine transporter (GlyT) …