This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

This critical review surveys the 3d substituted magnetic polyoxotungstate (POT) molecular
compounds reported these last ten years, illustrating the huge variety of topologies that …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Bisphosphonates, used for a long time in osteoporosis management, are currently the target
of intensive research, from pre-formulation studies to more advanced stages of clinical …

The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba
histolytica and Plasmodium falciparum in vitro have been determined, and selected …

Although bisphosphonates were first used as therapeutic agents to inhibit bone resorption in
the early 1970s, their mode of action at the molecular level has only become fully clear …

γδ T cells are the first line of defense against many infectious organisms and are also
involved in tumor cell surveillance and killing. They are stimulated by a broad range of small …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

The progresses made in the field of drug design to combat tropical protozoan parasitic
diseases, such as Chagas' disease, leishmaniasis, and sleeping sickness are discussed …

Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors
of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster …