Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance

S Nadar, T Khan, SG Patching, A Omri - Microorganisms, 2022 - mdpi.com
A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

Respiration-induced biofilm formation as a driver for bacterial niche colonization

AJ Martín-Rodríguez - Trends in Microbiology, 2023 - cell.com
Depending on their physiology and metabolism, bacteria can carry out diverse redox
processes for energy acquisition, which facilitates adaptation to environmental or host …

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics

AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …

Antibiofilm peptides: overcoming biofilm-related treatment failure

M Dostert, MJ Trimble, REW Hancock - RSC advances, 2021 - pubs.rsc.org
Health leaders and scientists worldwide consider antibiotic resistance among the world's
most dangerous pathogens as one of the biggest threats to global health. Antibiotic …

[HTML][HTML] Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review

DR Zhou, R Eid, KA Miller, E Boucher… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Alterations in the levels of numerous second messengers are ubiquitous responses to all
stresses that lead to apoptotic or hormetic responses. The sheer number and vast diversity …

Effect of Coix Seed Extracts on Growth and Metabolism of Limosilactobacillus reuteri

Z Yang, A Wen, L Qin, Y Zhu - Foods, 2022 - mdpi.com
Coix seed (Coix lachryma-jobi L.) is an important nourishing food and traditional Chinese
medicine. The role of their bioactive constituents in physiology and pharmacology has …

Diversity in E. coli (p)ppGpp Levels and Its Consequences

B Spira, K Ospino - Frontiers in Microbiology, 2020 - frontiersin.org
(p) ppGpp is at the core of global bacterial regulation as it controls growth, the most
important aspect of life. It would therefore be expected that at least across a species the …

Comparative genomics of cyclic di-GMP metabolism and chemosensory pathways in Shewanella algae strains: novel bacterial sensory domains and functional …

AJ Martín-Rodríguez, SM Higdon, K Thorell… - Msystems, 2022 - Am Soc Microbiol
Shewanella spp. play important ecological and biogeochemical roles, due in part to their
versatile metabolism and swift integration of stimuli. While Shewanella spp. are primarily …

Reduction of alternative electron acceptors drives biofilm formation in Shewanella algae

AJ Martín-Rodríguez, JA Reyes-Darias… - NPJ biofilms and …, 2021 - nature.com
Shewanella spp. possess a broad respiratory versatility, which contributes to the occupation
of hypoxic and anoxic environmental or host-associated niches. Here, we observe a strain …

Similar and divergent roles of stringent regulator (p) ppGpp and DksA on pleiotropic phenotype of Yersinia enterocolitica

C Huang, J Meng, W Li, J Chen - Microbiology Spectrum, 2022 - Am Soc Microbiol
Stringent response plays an important role in the response of Enterobacteriaceae
pathogens to rapid environmental changes. It has been shown that synergistic and …