This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

We define plant cyclopeptides [with the exception of the acyclic compounds lasiodine-A (1),
13 sanjoinine-G2 (2), 74 astin-J (216), 156 asternin-AC (217-219), 157 and MCoTI-III (462) …

The cyclotides constitute a recently discovered family of plant-derived peptides that have the
unusual features of a head-to-tail cyclized backbone and a cystine knot core. These features …

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein–
protein interactions. In contrast to the heavily automated high-throughput screening systems …

Proteins that are expressed outside the cell must be synthesized, folded, and assembled in
a way that ensures they can function in their designate location. Accordingly, these proteins …

Proteases can catalyze both peptide bond cleavage and formation, yet the hydrolysis
reaction dominates in nature. This presents an interesting challenge for the biosynthesis of …

Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

Cyclotides, a large family of cyclic peptides from plants, have a broad range of biological
activities, including insecticidal, cytotoxic, and anti-HIV activities. In all of these activities, cell …

Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized
peptide backbone and a knotted arrangement of three conserved disulfide bonds. They are …

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we
provide an update on the topology of the cystine knot and the combinatorial diversity of …