Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

Excitatory afferents to the nucleus accumbens (NAc) are thought to facilitate reward seeking
by encoding reward-associated cues. Selective activation of different glutamatergic inputs to …

It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively
increases over the first several weeks of abstinence and remains high for extended periods …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …

Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue
to do so despite negative consequences. Even after prolonged periods of abstinence …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …

In rat models of drug relapse and craving, cue-induced cocaine seeking progressively
increases after withdrawal from the drug. This' incubation of cocaine craving'is partially …