Metallothionein: a comprehensive review of its classification, structure, biological functions, and applications

R Yang, D Roshani, B Gao, P Li, N Shang - Antioxidants, 2024 - pmc.ncbi.nlm.nih.gov
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in
nature. In addition to heavy metal detoxification, metallothionein is well known as a potent …

Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease

A Shaikh, F Ahmad, SL Teoh, J Kumar… - Frontiers in Cellular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is characterized by the pathologic deposition of amyloid and
neurofibrillary tangles in the brain, leading to neuronal damage and defective synapses …

Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's

CE Toomey, WE Heywood, JR Evans, J Lachica… - Acta neuropathologica …, 2022 - Springer
Background The molecular drivers of early sporadic Parkinson's disease (PD) remain
unclear, and the presence of widespread end stage pathology in late disease masks the …

Parkinson's disease model in zebrafish using intraperitoneal MPTP injection

NA Omar, J Kumar, SL Teoh - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Parkinson's disease (PD) is the second most common neurodegenerative
disease that severely affects the quality of life of patients and their family members …

Zebrafish: A pharmacological model for learning and memory research

JK Tan, FH Nazar, S Makpol, SL Teoh - Molecules, 2022 - mdpi.com
Learning and memory are essential to organism survival and are conserved across various
species, especially vertebrates. Cognitive studies involving learning and memory require …

Acute deltamethrin exposure induces oxidative stress, triggers endoplasmic reticulum stress, and impairs hypoxic resistance of crucian carp

X Yuan, H Wu, J Gao, X Geng, M Xie, R Song… - … and Physiology Part C …, 2023 - Elsevier
Deltamethrin (Del) has been widely used for effectively controlling ectoparasites of crucian
carp and was also strictly prohibited in a hypoxic environment. A previous study indicated …

Inhibition of protein aggregation and endoplasmic reticulum stress as a targeted therapy for α-synucleinopathy

N Siwecka, K Saramowicz, G Galita… - Pharmaceutics, 2023 - mdpi.com
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous
system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release …

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson's disease model

NA Omar, J Kumar, SL Teoh - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the
development, maintenance and survival of neurons. This study aims to localize NT3 …

Dopamine release impairments accompany locomotor and cognitive deficiencies in rotenone-treated Parkinson's disease model zebrafish

P Hettiarachchi, SS Niyangoda… - Chemical research in …, 2022 - ACS Publications
In this work, we carried out neurochemical and behavioral analysis of zebrafish (Danio rerio)
treated with rotenone, an agent used to chemically induce a syndrome resembling …

Induction of Paraquat‐Mediated Parkinsonian Phenotype in Zebrafish

VS Harini, R Marimuthu, MSA Tantry… - Current …, 2024 - Wiley Online Library
Paraquat (PQ) is a well‐known neurotoxin closely associated with neurodegenerative
Parkinson's disease (PD). Zebrafish are utilized as a model for PD research because of their …