Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

Abstract ADAR1‐mediated A‐to‐I RNA editing is a self‐/non‐self‐discrimination mechanism
for cellular double‐stranded RNAs. ADAR mutations are one cause of Aicardi–Goutières …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands
as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in …

Adenosine to inosine editing (A-to-I) in regions of double stranded RNA (dsRNA) is
mediated by adenosine deaminase acting on RNA 1 (ADAR1) or ADAR2. ADAR1 and A-to-I …

Highlights•A-to-I RNA editing in hematopoietic cells is dynamic and cell type–
specific.•ADAR1 mediated A-to-I editing is essential for normal murine hematopoiesis.• …