Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

The ravaging effect of drug-resistant bacteria has heightened the need for the development
of membrane-soluble antimicrobial peptides (AMPs). However, their potential for clinical use …

Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and
progression of many types of tumors and thus β-catenin represents one attractive …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Easy access to a wide range of structurally diverse stapled peptides is crucial for the
development of inhibitors of protein‐protein interactions. Herein, we report bis‐functional …

While the global market for peptide/protein-based therapeutics is witnessing significant
growth, the development of peptide drugs remains challenging due to their low oral …

Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …

Stapled peptides are regarded as the promising next-generation therapeutics because of
their improved secondary structure, membrane permeability and metabolic stability as …

Establishing structure–activity relationships is crucial to understand and optimize the activity
of peptide-based inhibitors of protein–protein interactions. Single alanine substitutions …