The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

The need to protect neural tissue from toxins or other substances is as old as neural tissue
itself. Early recognition of this need has led to more than a century of investigation of the …

Background Brain metastasis (BM) is thought to be related to the mortality and poor
prognosis of non-small cell lung cancer (NSCLC). Despite promising development of …

Zebrafish have proved to be invaluable for modeling complex physiological processes
shared by all vertebrate animals. Resistance of cancers and other diseases to drug …

Abstract Cancer Drug Resistance publishes contributions to understanding the biology and
consequences of mechanisms that interfere with successful treatment of cancer. Since …

The ATP-binding cassette subfamily B member 1 (ABCB1), encoding a multidrug transporter
referred to as P-glycoprotein (Pgp), plays a critical role in the efflux of xenobiotics in humans …

Fluorescence imaging has become an essential tool in biomedical research. However, non-
invasive deep-tissue three-dimensional optical in vivo imaging with the high spatiotemporal …

ATP-binding cassette (ABC) transporters are believed to protect aquatic organisms by
pumping xenobiotics out, and recent investigation has suggested their involvement in the …

ABSTRACT Tilapia Lake Virus (TiLV) is associated with pathological changes in the brain of
infected fish, but the mechanisms driving the virus's neuropathogenesis remain poorly …

The blood‐brain barrier (BBB) is a highly controlled microenvironment that regulates the
interactions between cerebral blood and brain tissue. Due to its selectivity, many …