ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …

The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic
circulating low-density lipoprotein (LDL) cholesterol. Here we show that the …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Endosomes are major protein sorting stations in cells. Endosomally localised multi-protein
complexes sort integral proteins, including signaling receptors, nutrient transporters …

Hereditary spastic paraplegias (HSP) are rare neurodegenerative diseases sharing the
degeneration of the corticospinal tracts as the main pathological characteristic. They are …

Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

Cerebellar hypoplasia (CH) refers to a cerebellum with a reduced volume, and is a common,
but non‐specific neuroimaging finding. The etiological spectrum of CH is wide and includes …

CD4+ T cells are vital for host defense and immune regulation. However, the fundamental
role of CD4 itself remains enigmatic. We report seven patients aged 5–61 years from five …