Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

How does a protease act like a hormone to regulate cellular functions? The coagulation
protease thrombin (EC 3.4. 21.5) activates platelets and regulates the behavior of other cells …

Protease-activated receptor 2 (PAR2) is expressed by vascular endothelial cells and other
cells in which its function and physiological activator (s) are unknown. Unlike PAR1, PAR3 …

TISSUE factor, a member of the cytokine-receptor superfamily and high-affinity receptor and
cofactor for plasma factor Vll/VIIa (ref. 1), is the primary cellular initiator of blood coagulation …

The role of tissue factor (TF, thromboplastin) as the major player in initiation of the blood
coagulation process has been known for more than 100 years (1, 2). Its importance for …

Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide
range of cancer cells and plays important roles in cancer progression and metastasis …

After a coagulation stimulus, the blood clotting cascade amplifies largely unchecked until
very high levels of thrombin are generated. Natural anticoagulant mechanisms (for example …

Tissue factor (TF), a transmembrane receptor for coagulation factor VII/VIIa, is aberrantly
expressed in human cancers. We demonstrated a significant correlation between TF and …

Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood
coagulation, is believed to play an important role in tissue repair, inflammation …

Several studies have established a link between blood coagulation and cancer, and more
specifically between tissue factor (TF), a transmembrane protein involved in initiating blood …