Orofacial pain represents a multidisciplinary biomedical challenge involving basic and
clinical research for which no satisfactory solution has been found. In this regard, trigeminal …

Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a
mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and …

Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a
primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct …

The neurobiology of tumors has attracted considerable interest from clinicians and scientists
and has become a multidisciplinary area of research. Neural components not only interact …

Cancer-induced bone pain (CIBP) has a considerable impact on patients' quality of life as
well as physical and mental health. At present, patients with CIBP are managed according to …

Head and neck squamous cell carcinoma (HNSCC) patients report severe function-induced
pain at the site of the primary tumor. The current hypothesis is that oral cancer pain is …

Oral squamous cell carcinoma (OSCC) patients suffer from poor survival due to metastasis
or locoregional recurrence, processes that are both facilitated by perineural invasion (PNI) …

The nervous and immune systems are the primary sensory interfaces of the body, allowing it
to recognize, process, and respond to various stimuli from both the external and internal …

Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in
knowledge exists about comprehensive regulation of tissue-specific trigeminal sensory …

This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the
control of nociception and pain. BDNF, a neurotrophin known for its essential role in …