Recent developments in diagnosis of epilepsy: scope of MicroRNA and technological advancements

R Bandopadhyay, T Singh, MM Ghoneim, S Alshehri… - Biology, 2021 - mdpi.com
Simple Summary Through epilepsy is one of the leading causes of poor mental health,
increased school dropout, and socioeconomic burden, yet the diagnosis remains a …

MicroRNAs as potential biomarkers of post-traumatic epileptogenesis: a systematic review

AA Vasilieva, EE Timechko, KD Lysova… - International Journal of …, 2023 - mdpi.com
Structural or post-traumatic epilepsy often develops after brain tissue damage caused by
traumatic brain injury, stroke, infectious diseases of the brain, etc. Most often, between the …

Circulating microRNAs as potential novel diagnostic biomarkers to predict drug resistance in temporal lobe epilepsy: a pilot study

S De Benedittis, F Fortunato, C Cava… - International Journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential
epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously …

Down-regulation of lncRNA SNHG5 relieves sepsis-induced acute kidney injury by regulating the miR-374a-3p/TLR4/NF-κB pathway

M Wang, J Wei, F Shang, K Zang… - The journal of …, 2021 - academic.oup.com
Sepsis is an acute systemic infectious disease engendered by infectious factors, which can
cause the dysfunction of multiple organs, including acute kidney injury (AKI). Recently, more …

microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients

Q Wang, X Shi, PP Li, L Gao, Y Zhou, L Li, H Ye… - Pediatric …, 2024 - nature.com
Background Although previous studies show that microRNAs (miRNAs) can potentially be
used as diagnostic markers for epilepsy, there are very few analyses of pediatric epilepsy …

Dysregulation of miR-146a: a causative factor in epilepsy pathogenesis, diagnosis, and prognosis

S Mao, J Wu, J Yan, W Zhang, F Zhu - Frontiers in Neurology, 2023 - frontiersin.org
miR-146a is an NF-κB-dependent miRNA that acts as an anti-inflammatory miRNA via the
Toll-like receptor (TLR) pathway. miR-146a targets multiple genes and has been identified …

Circulating miR-146a-5p and miR-132–3p as potential diagnostic biomarkers in epilepsy

AM Nomair, JF Mekky, SA El-Hamshary, HM Nomeir - Epilepsy Research, 2023 - Elsevier
Objective MiRNAs are important gene-regulating agents in epilepsy development, according
to new research. The purpose of this study is to investigate the relationship between serum …

Liquid biopsies in epilepsy: biomarkers for etiology, diagnosis, prognosis, and therapeutics

JH Whitlock, TM Soelter, AS Williams, AA Hardigan… - Human Cell, 2022 - Springer
Epilepsy is one of the most common diseases of the central nervous system, impacting
nearly 50 million people around the world. Heterogeneous in nature, epilepsy presents in …

miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy

H Zheng, L Wu, H Yuan - Open Medicine, 2023 - degruyter.com
GRIN2A is associated with epilepsy (EP); however, its regulatory mechanism involving
upstream miRNA (miR-30b-5p) has been overlooked. In this study, we aimed to identify the …

Circulating miRNAs as Novel Clinical Biomarkers in Temporal Lobe Epilepsy

L Guarnieri, N Amodio, F Bosco, S Carpi, M Tallarico… - Non-coding RNA, 2024 - mdpi.com
Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy.
The identification of innovative clinical biomarkers capable of categorizing patients with TLE …