Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

The synaptic vesicle protein Synaptophysin (Syp) has long been known to form a complex
with the Vesicle associated soluble N-ethylmaleimide sensitive fusion protein attachment …

Highlights•Syts also regulate endocytosis and vesicle trafficking, not just
exocytosis.•Neurons as well as glia employ synaptotagmins (Syts) for diverse …

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs
are constitutively active, so a major focus has been to identify fusion clamps that regulate …

Synaptic neurotransmitter release is mediated by an orchestra of presynaptic proteins that
precisely control and trigger fusion between synaptic vesicles and the neuron terminal at the …

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental
process that is central to all information processing in the brain. This relies on tight coupling …

The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …

Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea
that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) …