Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

In clinical practice, we often deal with patients who suffer from non-alcoholic fatty liver
disease (NAFLD) concurrent with type 2 diabetes mellitus (T2DM). The etiopathogenesis of …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic
acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of …

The prevalence of nonalcoholic fatty liver disease (NAFLD) in the general population is
estimated at 25%, and there is currently no effective treatment of NAFLD. Although insulin …

The hypothesis that dietary (poly) phenols promote well‐being by improving chronic disease‐
risk biomarkers, such as endothelial dysfunction, chronic inflammation and plasma uric acid …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic
acid (PA). Mammalian DGK comprises ten isozymes (α–κ) and regulates a wide variety of …

Recent evidence indicates that saturated fatty acid–induced (SFA-induced) lipotoxicity
contributes to the pathogenesis of cardiovascular and metabolic diseases; however, the …

Diacylglycerol kinases (DGKs) catalyze a reaction that converts diacylglycerol (DAG) to
phosphatidic acid (PA). DAG and PA act as intermediates of de novo lipid synthesis, cellular …

Diets enriched in fructose (FR) increase lipogenesis in the liver, leading to hepatic lipid
accumulation and the development of insulin resistance. Previously, we have shown that in …