Sulfur metabolism-mediated fungal glutathione biosynthesis is essential for oxidative stress resistance and pathogenicity in the plant pathogenic fungus Fusarium …

J Park, JW Han, N Lee, S Kim, S Choi, HH Lee, JE Kim… - Mbio, 2024 - Am Soc Microbiol
The oxidative stress response is required for plant pathogens to endure host-derived
oxidative stress during infection. Previously, we identified the eight transcription factors (TFs) …

[HTML][HTML] Siderophore Biosynthesis and Transport Systems in Model and Pathogenic Fungi

S Choi, JW Kronstad, WH Jung - Journal of microbiology and …, 2024 - ncbi.nlm.nih.gov
Fungi employ diverse mechanisms for iron uptake to ensure proliferation and survival in iron-
limited environments. Siderophores are secondary metabolite small molecules with a high …

Synergistic antifungal effect of a combination of iron deficiency and calcium supplementation

J Ye, Y Wang, X Li, Q Wan, Y Zhang… - Microbiology Spectrum, 2022 - Am Soc Microbiol
Fungal diseases have become a major public health issue worldwide. Increasing drug
resistance and the limited number of available antifungals result in high morbidity and …

Monothiol Glutaredoxin Is Essential for Oxidative Stress Protection and Virulence in Pseudomonas aeruginosa

K Saninjuk, A Romsang, J Duang-Nkern… - Applied and …, 2023 - Am Soc Microbiol
Glutaredoxins (Grxs), ubiquitous redox enzymes belonging to the thioredoxin family,
catalyze the reduction of thiol-disulfide exchange reactions in a glutathione-dependent …

Unraveling the pathobiological role of the fungal KEOPS complex in Cryptococcus neoformans

Y Choi, E Jeong, DG Lee, JH Jin, YS So, SR Yu… - Mbio, 2022 - Am Soc Microbiol
The KEOPS (k inase, putative e ndopeptidase, and o ther p roteins of s mall size) complex
has critical functions in eukaryotes; however, its role in fungal pathogens remains elusive …

A Transcriptional Regulatory Map of Iron Homeostasis Reveals a New Control Circuit for Capsule Formation in Cryptococcus neoformans

E Do, YJ Cho, D Kim, JW Kronstad, WH Jung - Genetics, 2020 - academic.oup.com
Transcriptional Regulatory Map of Iron Homeostasis Reveals a New Control Circuit for
Capsule Formation in Cryptococcus neoformans | Genetics | Oxford Academic Skip to Main …

Strain variation in the Candida albicans iron limitation response

L Xiong, K Goerlich, E Do, AP Mitchell - Msphere, 2024 - journals.asm.org
Iron acquisition is critical for pathogens to proliferate during invasive infection, and the
human fungal pathogen Candida albicans is no exception. The iron regulatory network …

The interplay between electron transport chain function and iron regulatory factors influences melanin formation in Cryptococcus neoformans

P Xue, E Sánchez-León, G Hu, CWJ Lee, B Black… - Msphere, 2024 - Am Soc Microbiol
Mitochondrial functions are critical for the ability of the fungal pathogen Cryptococcus
neoformans to cause disease. However, mechanistic connections between key functions …

A cytoplasmic heme sensor illuminates the impacts of mitochondrial and vacuolar functions and oxidative stress on heme-iron homeostasis in Cryptococcus …

G Bairwa, E Sánchez-León, E Do, WH Jung… - Mbio, 2020 - Am Soc Microbiol
Pathogens must compete with hosts to acquire sufficient iron for proliferation during
pathogenesis. The pathogenic fungus Cryptococcus neoformans is capable of acquiring iron …