Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Generation of functional transcripts requires transcriptional initiation at regular start sites,
avoiding production of aberrant and potentially hazardous aberrant RNAs. The mechanisms …

Research advances in airway remodeling in asthma: a narrative review - PMC Back to Top
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Rationale: Pediatric obesity-related asthma is a nonatopic asthma phenotype with high
disease burden and few effective therapies. RhoGTPase upregulation in peripheral blood T …

Background Severe asthma is a chronic lung disease characterised by inflammation, airway
hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms …

Fibrostenosing Crohn's disease (CD) represents a challenging clinical condition
characterized by the development of symptomatic strictures within the gastrointestinal tract …

Airway smooth muscle (ASM) cell dysfunction is an important component of several
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …

Sex/gender difference exists in the physiology of multiple organs. Recent epidemiological
reports suggest the influence of sex-steroids in modulating a wide variety of disease …

Major esophageal disorders involve obstructive transport of bolus to the stomach, causing
symptoms of dysphagia and impaired clearing of the refluxed gastric contents. These may …