Lifelong hematopoiesis is sustained by crosstalk between hematopoietic stem and
progenitor cells (HSPCs) and specialized bone marrow niches. Acute myeloid leukemia …

Leukemia is a malignant tumor with high heterogeneity and a complex evolutionary process.
It is difficult to resolve the heterogeneity and clonal evolution of leukemia cells by applying …

The development of myeloid malignancies is influenced by a range of cell-intrinsic and cell-
extrinsic factors, which can be conceptualized using the hallmarks of cancer. Although many …

Acute myeloid leukaemia (AML) management remains a significant challenge in oncology
due to its low survival rates and high post-treatment relapse rates, mainly attributed to …

Background: Exploring potential biomarkers for predicting clinical outcomes and developing
targeted therapies for acute myeloid leukemia (AML) is of utmost importance. This study …

Acute myeloid leukemia (AML) is a heterogeneous group of malignancies with poor
prognosis. AML result from the proliferation of immature myeloid cells blocked at a variable …

Pediatric acute myeloid leukemia (pAML) is a clonal disease with recurrent genetic
alterations that affect epigenetic states. However, the implications of epigenetic …

Recent models of infection and experimental inflammation reveal that hematopoietic stem
and progenitor cells (HSPCs) can generate a memory of the exposure that heightens the …

The role of microenvironmental inflammation in the regulation of acute myeloid leukemia
(AML) and stressed hematopoiesis is significant, though the molecular mechanisms are not …