Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
Peptides, peptidomimetics, and carbohydrate–peptide conjugates as amyloidogenic aggregation inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for 60–
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …
Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model
GK Viswanathan, D Shwartz, Y Losev, E Arad… - Cellular and Molecular …, 2020 - Springer
Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …
Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers
SK Sonawane, AA Balmik, D Boral… - Archives of biochemistry …, 2019 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder caused by protein misfolding,
aggregation and accumulation in the brain. A large number of molecules are being …
aggregation and accumulation in the brain. A large number of molecules are being …
O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease
Post-translational modifications (PTMs) of proteins are becoming the focus of intense
research due to their implications in a broad spectrum of neurodegenerative diseases …
research due to their implications in a broad spectrum of neurodegenerative diseases …
Challenges and opportunities in central nervous system drug discovery
The development of new drugs for disorders of the central nervous system (CNS) presents
unique challenges when compared with other disease areas. These include an incomplete …
unique challenges when compared with other disease areas. These include an incomplete …
[图书][B] Studies in natural products chemistry
A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
Neuroprotection of multifunctional phytochemicals as novel therapeutic strategy for neurodegenerative disorders: Antiapoptotic and antiamyloidogenic activities by …
M Naoi, M Shamoto-Nagai, W Maruyama - Future Neurology, 2019 - Taylor & Francis
In neurodegenerative disorders, including Alzheimer's and Parkinson's disease,
neuroprotection by diet and natural bioactive compounds has been proposed to prevent the …
neuroprotection by diet and natural bioactive compounds has been proposed to prevent the …
Design of a selective and water-soluble fluorescent probe targeting Tau fibrils for intracellular and in vivo imaging
L Ji, X Zhou, R Liu, L Wang, Y Hu, J Gu, Z Li… - Sensors and Actuators B …, 2023 - Elsevier
Tau protein has attracted much research interest in recent years. Development of effective
techniques for in vivo imaging of Tau protein with high sensitivity and selectivity is of great …
techniques for in vivo imaging of Tau protein with high sensitivity and selectivity is of great …
Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …