The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
The ever-increasing array of novel inborn errors of immunity: an interim update by the IUIS committee
SG Tangye, W Al-Herz, A Bousfiha… - Journal of clinical …, 2021 - Springer
The most recent updated classification of inborn errors of immunity/primary
immunodeficiencies, compiled by the International Union of Immunological Societies Expert …
immunodeficiencies, compiled by the International Union of Immunological Societies Expert …
Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee
SG Tangye, W Al-Herz, A Bousfiha… - Journal of clinical …, 2022 - Springer
We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …
International Union of Immunological Societies Expert Committee. This report documents the …
Polyclonal expansion of TCR Vβ 21.3+ CD4+ and CD8+ T cells is a hallmark of multisystem inflammatory syndrome in children
M Moreews, K Le Gouge, S Khaldi-Plassart… - Science …, 2021 - science.org
Multisystem inflammatory syndrome in children (MIS-C) is a delayed and severe
complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
SOCS proteins in immunity, inflammatory diseases, and immune-related cancer
Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …
complex responses required to facilitate appropriate immune cell development and function …
Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story
M Bonelli, A Kerschbaumer, K Kastrati… - Annals of the rheumatic …, 2024 - Elsevier
Fundamental insight gained over the last decades led to the discovery of cytokines as
pivotal drivers of inflammatory diseases such as rheumatoid arthritis, psoriasis/psoriasis …
pivotal drivers of inflammatory diseases such as rheumatoid arthritis, psoriasis/psoriasis …
JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition
Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …
STAT) pathway has become recognized as a central mediator of widespread and varied …
JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences
N Ott, L Faletti, M Heeg, V Andreani… - Journal of clinical …, 2023 - Springer
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6
Background Inborn errors of immunity have been implicated in causing immune
dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses …
dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses …
SOCS1 is a critical checkpoint in immune homeostasis, inflammation and tumor immunity
GM Bidgood, N Keating, K Doggett… - Frontiers in …, 2024 - frontiersin.org
The Suppressor of Cytokine Signaling (SOCS) family proteins are important negative
regulators of cytokine signaling. SOCS1 is the prototypical member of the SOCS family and …
regulators of cytokine signaling. SOCS1 is the prototypical member of the SOCS family and …