African sleeping sickness, Chagas disease, and leishmaniasis are life-threatening diseases
that together affect millions of people around the world and are caused by different members …

Animal trypanosomiasis (AT) is a complex of veterinary diseases known under various
names such as nagana, surra, dourine and mal de caderas, depending on the country, the …

Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei, is one of the
neglected tropical diseases with a continuing need for new medication. We here describe …

Chagas disease and visceral leishmaniasis are two neglected tropical diseases responsible
for numerous deaths around the world. For both, current treatments are largely inadequate …

The study of transporters is highly challenging, as they cannot be isolated or studied in
suspension, requiring a cellular or vesicular system, and, when mediated by more than one …

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given
the limited therapeutic options and problems of toxicity and drug resistance, this study …

Chagas disease and leishmaniasis are two poverty-related neglected tropical diseases that
cause high mortality and morbidity. Current treatments suffer from severe limitations and …

Human African trypanosomiasis is a neglected tropical disease caused by Trypanosoma
brucei parasites. These protists are unable to produce the purine ring, making them …

Purines and pyrimidines are essential nutrients for any cell. Most organisms are able to
synthesize their own purines and pyrimidines, but this ability was lost in protozoans that …