Biological, biochemical and physical stimuli activate inflammatory leukocytes, such as
macrophages, resulting in induction and synthesis of proinflammatory proteins and …

A role for the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis
factor alpha (TNF-α) is evident in term and preterm delivery, and this is independent of the …

Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and
angiogenesis. To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and …

The relationship between hypoxia and regulation of nitric oxide synthase (NOS) in
myocardial tissue is not well understood. We investigated the role of hypoxia inducible factor …

Mononuclear cell infiltration and local cytokine elaboration are hallmarks of inflammatory
and immunologic heart diseases. To test the hypothesis that cytokines can modulate cardiac …

Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthases in the central
nervous system. Here, the roles of nitric oxide in the central nervous system are reviewed …

Interleukin-1 (IL-1), initially called" endogenous pyrogen," is primarily known as a mediator
of inflammation. However, it also plays many other diverse physiologic roles including the …

There is accumulating evidence that endothelial cells express a non-isopeptide-selective
endothelin (ET) receptor, ETB, which may be responsible for ET-1-induced transient …

Interleukin-1 (IL-1) is primarily an inflammatory cytokine, although it is capable of mediating
a wide variety of effects on many different cell types. Nearly every known signal transduction …

Septic shock results from excessive stimulation of the host immune system, especially
macrophages, by lipopolysaccharide (LPS), or endotoxin, which resides on the outer …