Myeloid-derived suppressor cells as a therapeutic target for cancer
The emergence of immunotherapy has been an astounding breakthrough in cancer
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
Interleukin-1 and related cytokines in the regulation of inflammation and immunity
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …
that involves activation and consumption of immune cells in order to reestablish and …
Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
From haematopoietic stem cells to complex differentiation landscapes
E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
Myeloid immunosuppression and immune checkpoints in the tumor microenvironment
K Nakamura, MJ Smyth - Cellular & molecular immunology, 2020 - nature.com
Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …
C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells
B de Laval, J Maurizio, PK Kandalla, G Brisou… - Cell stem cell, 2020 - cell.com
Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can
directly respond to infection, but sustained effects on the immune response remain unclear …
directly respond to infection, but sustained effects on the immune response remain unclear …
The evolutionary dynamics and fitness landscape of clonal hematopoiesis
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …
Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis
Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …
Emergency granulopoiesis
MG Manz, S Boettcher - Nature Reviews Immunology, 2014 - nature.com
Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …
to be continuously generated in steady-state conditions from haematopoietic stem and …