Targeting protein-protein interactions (PPIs) has been recently recognized as an emerging
therapeutic approach for several diseases. Up today, more than half a million PPI …

Background & Aims Irritable bowel syndrome (IBS) is a common disorder of gut–brain
interaction associated with significant disease burden. This American Gastroenterological …

Enteroendocrine cells (EECs) are an essential interface between the gut and brain that
communicate signals about nutrients, pain, and even information from our microbiome …

Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a
key bottleneck in oral peptide drug development. Here, we present a systematic analysis of …

Functional gastrointestinal disorders (FGID), such as functional dyspepsia (FD) and irritable
bowel syndrome (IBS) are characterized by chronic abdominal symptoms in the absence of …

Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …

Constipation, a condition characterized by heterogeneous symptoms, is common in Western
society. It is associated with reduced physical health, mental health, and social functioning …

Neurological and psychiatric patients have increased dramatically in number in the past few
decades. However, effective treatments for these diseases and disorders are limited due to …

Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic
options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP (cGMP) …

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by
abdominal pain and altered bowel habit that affects~ 11% of the global population. Over the …