Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …

Mitochondrial damage causes mitochondrial DNA (mtDNA) release to activate the type I
interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation …

Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to
prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Mutations in the genes for PINK1 and parkin cause Parkinson's disease. PINK1 and parkin
cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in …

The mitochondrial inner membrane can reshape under different physiological conditions.
How, at which frequency this occurs in living cells, and the molecular players involved are …

Summary PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of
damaged mitochondria through Parkin translocation and mitophagy. Because the short half …