The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …

Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …

Comparing the pathogen genomes from several cases of an infectious disease has the
potential to help us understand and control outbreaks. Many methods exist to reconstruct a …

Background Whole genome sequencing (WGS) is a reliable tool for studying tuberculosis
(TB) transmission. WGS data are usually processed by custom-built analysis pipelines with …

Aim The purpose of this viewpoint is to summarize the advantages and constraints of the
tools and strategies available for reducing the annual incidence of tuberculosis (TB) by …

Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and
histopathologic manifestations. It has been proposed that the environmental and immune …

Tuberculosis (TB) control programs use whole-genome sequencing (WGS) of
Mycobacterium tuberculosis (Mtb) for detecting and investigating TB case clusters. Existence …

Background The analysis of transmission of tuberculosis (TB) is challenging in areas with a
large migrant population. Standard genotyping may fail to differentiate transmission within …

The Kingman coalescent and its developments are often considered among the most
important advances in population genetics of the last decades. Demographic inference …

Denmark, a tuberculosis low burden country, still experiences significant active
Mycobacterium tuberculosis (Mtb) transmission, especially with one specific genotype …