Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of
a central core protein with covalently linked glycosaminoglycan (GAG) chains; both of these …

Baratela-Scott syndrome (BSS) is a rare, autosomal-recessive disorder characterized by
short stature, facial dysmorphisms, developmental delay, and skeletal dysplasia caused by …

Most eukaryotic cells elaborate several proteoglycans critical for transmitting biochemical
signals into and between cells. However, the regulation of proteoglycan biosynthesis is not …

Desbuquois dysplasia (DBQD) is a severe condition characterized by short stature, joint
laxity, and advanced carpal ossification. Based on the presence of additional hand …

Recently repeat expansions have been found in more than 10 diseases in the past two
years. Because the same repeat motifs are found in similar disease (as exemplified by …

Skeletal dysplasias result from disruptions in normal skeletal growth and development and
are a major contributor to severe short stature. They occur in approximately 1/5,000 births …

Heparan and chondroitin/dermatan sulfated proteoglycans have a wide range of roles in
cellular and tissue homeostasis including growth factor function, morphogen gradient …

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …

Glycosaminoglycans (GAG s) are a heterogeneous family of linear polysaccharides that
constitute the carbohydrate moiety covalently attached to the protein core of proteoglycans …