Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance

HS Tuli, S Mittal, D Aggarwal, G Parashar… - Seminars in Cancer …, 2021 - Elsevier
In the last few decades, targeting cancer by the use of dietary phytochemicals has gained
enormous attention. The plausible reason and believe or mind set behind this fact is …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway

MA Rahman, MA Hannan, R Dash… - Frontiers in …, 2021 - frontiersin.org
Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …

[HTML][HTML] Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells

TZ Lopes, FR de Moraes, AC Tedesco, RK Arni… - Biomedicine & …, 2020 - Elsevier
Renal cell carcinoma (RCC) consists of the most lethal common urological cancer and the
clinical practice has shown that resistant RCC to commons therapies is extremely high …

Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway

S Fakhri, SZ Moradi, SY Moradi, S Piri… - BMC cancer, 2024 - Springer
Background Due to the complex pathophysiological mechanisms involved in cancer
progression and metastasis, current therapeutic approaches lack efficacy and have …

Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells

X Feng, L Chen, W Guo, Y Zhang, X Lai, L Shao, Y Li - Acta biomaterialia, 2018 - Elsevier
Graphene oxide (GO), as a two-dimensional carbon nanosheet, has been extensively
studied for potential biomedical applications due to its notable properties. Although a …

Plant polyphenols for aging health: Implication from their autophagy modulating properties in age-associated diseases

JM Brimson, MI Prasanth, DS Malar, P Thitilertdecha… - Pharmaceuticals, 2021 - mdpi.com
Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits,
vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic …

Graphene oxide ameliorates the cognitive impairment through inhibiting PI3K/Akt/mTOR pathway to induce autophagy in AD mouse model

F Chu, K Li, X Li, L Xu, J Huang, Z Yang - Neurochemical Research, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system
characterised by cognitive impairment. Its major pathological feature is the deposition of β …

Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF

C Wang, C He, S Lu, X Wang, L Wang, S Liang… - Cell Death & …, 2020 - nature.com
Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains
elusive whether autophagy contributes to cell death via causing mitochondria damage and …