Clinical translation of long-acting drug delivery formulations

W Li, J Tang, D Lee, TR Tice… - Nature Reviews …, 2022 - nature.com
Most pharmaceuticals are given using short-acting formulations that require frequent
administration, which can negatively affect patient compliance and increase failure risks …

Clinically established biodegradable long acting injectables: an industry perspective

CI Nkanga, A Fisch, M Rad-Malekshahi… - Advanced drug delivery …, 2020 - Elsevier
Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

Poly (lactic-co-glycolic acid) microsphere production based on quality by design: a review

Y Hua, Y Su, H Zhang, N Liu, Z Wang, X Gao, J Gao… - Drug Delivery, 2021 - Taylor & Francis
Poly (lactic-co-glycolic acid)(PLGA) has garnered increasing attention as a candidate drug
delivery polymer owing to its favorable properties, including its excellent biocompatibility …

Formulation composition, manufacturing process, and characterization of poly (lactide-co-glycolide) microparticles

K Park, A Otte, F Sharifi, J Garner, S Skidmore… - Journal of Controlled …, 2021 - Elsevier
Injectable long-acting formulations, specifically poly (lactide-co-glycolide)(PLGA) based
systems, have been used to deliver drugs systemically for up to 6 months. Despite the …

[HTML][HTML] Natural biopolyester microspheres with diverse structures and surface topologies as micro-devices for biomedical applications

ZY Wang, XW Zhang, YW Ding, ZW Ren… - Smart Materials in …, 2023 - Elsevier
Based on their excellent biocompatibility and adjustable biodegradability, the two natural
polyesters polylactic acid (PLA) and polyhydroxyalkanoates (PHAs) have been widely used …

How agarose gels surrounding PLGA implants limit swelling and slow down drug release

C Bassand, J Verin, M Lamatsch, F Siepmann… - Journal of Controlled …, 2022 - Elsevier
The aim of this study was to better understand to which extent and in which way the
presence of an agarose gel (mimicking living tissue) around a PLGA [poly (lactic-co-glycolic …

Current and future directions of drug delivery for the treatment of mental illnesses

PR Brewster, SMI Bari, GM Walker, TA Werfel - Advanced Drug Delivery …, 2023 - Elsevier
Mental illnesses including anxiety disorders, autism spectrum disorder, post-traumatic stress
disorder, schizophrenia, depression, and others exact an immense toll on the healthcare …

The management of Parkinson's disease: An overview of the current advancements in drug delivery systems

DD Nakmode, CM Day, Y Song, S Garg - Pharmaceutics, 2023 - mdpi.com
Parkinson's disease (PD) has significantly affected a large proportion of the elderly
population worldwide. According to the World Health Organization, approximately 8.5 million …

Transscleral delivery of dexamethasone-loaded microparticles using a dissolving microneedle array

R Fitaihi, S Abukhamees, M Orlu, DQM Craig - Pharmaceutics, 2023 - mdpi.com
Microneedles (MNs) have attracted considerable interest as a means of ocular drug delivery,
a challenging delivery route due to the limitations imposed by the various biological barriers …

Key Factor Study for Generic Long-Acting PLGA Microspheres Based on a Reverse Engineering of Vivitrol®

Y Hua, Z Wang, D Wang, X Lin, B Liu, H Zhang, J Gao… - Molecules, 2021 - mdpi.com
The FDA (US Food and Drug Administration) has approved only a negligible number of poly
(lactide-co-glycolide)(PLGA)-based microsphere formulations, indicating the difficulty in …